MSD, MSD Manual, Overview of Allergic and Atopic Disorders, 2020-10 ([Internet, 2021-08-18](https://www.msdmanuals.com/professional/immunology-allergic-disorders/allergic,-autoimmune,-and-other-hypersensitivity-disorders/overview-of-allergic-and-atopic-disorders))
Type II reactions (antibody-dependent cytotoxic hypersensitivity) result when an antibody binds to cell surface antigens or to a molecule coupled to a cell surface. The antigen-antibody complex activates cells that participate in or complement antibody-dependent cell-mediated cytotoxicity (...), or both. The result is cell and tissue damage.